Can we make it compatible with SHIMADZU instruments just by adjusting the "take off" to 52.5?
One can certainly edit the takeoff field in Probe for EPMA for 52.5 degrees, as the software was originally written for the ARL SEMQ microprobe, which had a takeoff angle of 52.5 degrees and was what the modern Shimadzu instrument is based on.
Here is an old picture of me on the ARL SEMQ instrument:

On that ARL instrument the Probe for EPMA instrument interface was based on PC boards for ISA (originally) and PCI (later) boards for motion control, pulse counting and A/D and D/A for imaging. However these boards became harder and harder to source and eventually as JEOL (8900) and Cameca (SX100) came out with (TCP/IP) network based instruments, Probe for EPMA dropped support for the ARL SEMQ instrument and was modified for TCP/IP interfacing. Though as shown in the previous post, PFE still (in theory) supports a 6 spectrometer instrument!
So while one can configure Probe for EPMA for a 6 spectrometer 52.5 degree takeoff angle instrument there is currently no network communication interface for the Shimadzu instrument. At one time we had some discussions with Shimadzu as to whether they could provide a TCP/IP network based interface, as we have for the JEOL and Cameca instruments, but it seems that their instrument interface is, like the old ARL SEMQ, based on PCI boards in a single PC, though that could have changed since our discussions many years ago.
It would be possible to add an additional instrument interface to Probe for EPMA, but I am afraid that network interface does not exist on the Shimadzu instrument. Basically a TCP/IP network interface is required in order for multiple computers to connect to and control the instrument at the same time.