Just wanted to let folks know that Cisco AMP for Endpoints may interfere with the proper functioning of Probe for EPMA. This is a virus scanner/network threat detection tool recently pushed by our organization. The symptom, when running PFE (on Windows 10 in our case), is a popup box titled "PositionGetSampleData" with a message reading "Could not lock file." Any PFE process running at the time the error is thrown is halted. A temporary workaround is to disable the Cisco AMP program.
To disable the program, you'll first want to disconnect from the network which provides your internet access. This is because shutting off your antivirus software will leave your machine vulnerable to viruses, malware, network attacks, etc. Next, to stop the Cisco AMP program on a Windows 10 machine, click on the Processes tab in Task Manager. Find Cisco AMP Tray Client, and click End Task. Also, find Cisco AMP for Endpoints Connector and do the same. This should take care of it. Remember to re-enable Cisco AMP once you're finished using PFE!
As I suggested, this is a temporary workaround, as you may want your machine to have internet access on a regular basis. Another possible workaround is to add exclusions to Cisco AMP for PFE. When I have time, I may experiment with this to see whether Cisco AMP and PFE can be made to peacefully coexist.
Cheers!
Paul Burger